Calculation of Optimal Pharmacokinetic-equation Parameters in Drugs by Intravenous Administration Using Excel Programming Solution
- VernacularTitle:利用Excel规划求解法计算药物静脉注射药动学方程参数最优解
- Author:
Jin YUAN
;
Jinhui PU
;
Shujin ZHAO
- Publication Type:Journal Article
- Keywords:
Excel;
Programming solution;
Intravenous administration;
Pharmacokinetics;
Parameters
- From:
China Pharmacy
2005;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a simple method for calculating the optimal pharmacokinetic-equation parameters in drugs by intravenous administration using Excel programming solution.METHODS:The pharmacokinetic parameters and compartment model parameters after intravenous injection drugs were computed by means of Excel programming solution,and the results were compared with those computed by DAS method or residual method.RESULTS:By means of Excel programming solution,the optimal pharmacokinetic parameters of one-and two-compartment models were obtained,which were completely in line with those computed by DAS program.CONCLUSION:Excel programming solution is applicable for the computation of the pharmacokinetic parameters of one-and two-compartment models following intravenous injection drugs.
