Effects of Trimetazidine on the Levels of Endothelin and Nitrogen Monoxidum in Patients with Unstable Angina Pectoris
- VernacularTitle:曲美他嗪对不稳定型心绞痛患者内皮素、一氧化氮水平的影响
- Author:
Pan XIONG
;
Li ZHOU
;
Aizhi DONG
- Publication Type:Journal Article
- Keywords:
Trimetazidine;
Unstable angina pectoris;
Endothelin;
Nitric oxide
- From:
China Pharmacy
2005;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of trimetazidine on endothelin and nitric oxide(NO)in patients with unstable angina pectoris.METHODS:80 patients with unstable angina pectoris were randomly assigned to trimetazidine group(n=40)or conventional treatment group(n=40).The levels of endothelin(ET)and NO before treatment and at 4 weeks after treatment were determined.Meanwhile,another 40 healthy volunteers were assigned to normal control group and their fasting levels of ET and NO on resting were determined.RESULTS:In unstable angina pectoris patients,the NO level decreased significantly but plasma ET level increased significantly,showing significant difference as compared with the normal control group(P0.05).The level of NO increased markedly and the ET level decreased markedly in trimetazidine-treated group after treatment,showing significant differences as compared with before treatment(P
