Clinical Study on Paroxetine Combined with Small Dose of Doxepin for Somatization Disorder
- VernacularTitle:帕罗西汀联用小剂量多塞平治疗躯体化障碍的临床研究
- Author:
Chengyong JIANG
;
Junliang CHEN
;
Hailong JIN
- Publication Type:Journal Article
- Keywords:
Paroxetine;
Doxepin;
Somatization disorder
- From:
China Pharmacy
2005;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the efficacy and adverse effects of paroxetine alone or in combination with small dose of doxepin for somatization disorder.METHODS:280 patients with somatization disorder were randomly assigned to receive paroxetine alone or in combination with small dose of doxepin for 8 weeks.Clinical global impression scale(CGI)and symptom check list(SCL-90)were used to assess the efficacy,and treatment emergent symptom scale(TESS)was used to assess the adverse effects.RESULTS:After treatment for 8 weeks,CGI score showed the total effective rate was 87.5% in the patients treated with paroxetine alone versus 93.8% in those treated with paroxetine in combination with small dose of doxepin(P0.05).CONCLUSION:Paroxetine in combination with small dose doxepin showed better efficacy for somatization disorder yet without increasing adverse effects as compared with paroxetine alone.
