The effect of tranexamic acid used for spine surgery on blood loss and transfused volume.
- Author:
Tae Joong YOO
1
;
Seung Gyu JEON
;
Sangseok LEE
;
Kye Min KIM
;
Jun Heum YON
;
Ki Hyuk HONG
Author Information
1. Department of Anesthesiology and Pain Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea. siestalee@gmail.com
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
antifibrinolytic agents;
spinal fusion;
tranexamic acid
- MeSH:
Anesthesia, General;
Antifibrinolytic Agents;
Blood Platelets;
Hemoglobins;
Humans;
Partial Thromboplastin Time;
Postoperative Period;
Prothrombin Time;
Spinal Fusion;
Spine;
Thrombelastography;
Tranexamic Acid
- From:Anesthesia and Pain Medicine
2009;4(2):106-112
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: In this randomized controlled study, we evaluate the effect of tranexamic acid on perioperative blood loss and transfused volume in patients undergoing spine surgery. METHODS: We enrolled and randomly allocated 40 patients scheduled for spine surgery under general anesthesia to either tranexamic group or control group. Tranexamic acid was given to tranexamic group with loading dose 10 mg/kg for 15 minutes followed by continuous infusion at the rate of 1 mg/kg/h. In control group, equivalent volume of normal saline was given with the same manner and rate, until the end of procedure. We examined the total blood loss and transfused volume perioperatively. Also we evaluated hemoglobin, platelet, prothrombin time, partial thromboplastin time and thromboelastography before and after surgery. RESULTS: The groups did not differ significantly. Intraoperative blood loss was 1,130.0 +/-563.9 (mean +/-SD) ml in control group and 1,061.5 +/-509.7 ml in tranexamic group. Blood loss at postoperative 12 h and 24 h were 392.0 +/-222.0 ml, 466.0 +/-323.2 ml in control group and 158.5 +/-100.6 ml, 470.2 +/-232.7 ml in tranexamic group respectively. Transfused volumes at intraoperative and postoperative period were differing significantly (1,300.0 +/-709.3 ml, 800.0 +/-343.3 ml in control group compared to 1,020.0 +/-476.3 ml, 340.0 +/-325.0 ml in tranexamic group). CONCLUSIONS: Loading dose of 10 mg/kg tranexamic acid and followed infusion at 1 mg/kg/h reduce perioperative blood transfused volume during spinal surgery.
