Effects of new drug of sulfonylurea on the glucose uptake in SMMC7721 cells
- VernacularTitle:新磺酰脲药物BGW刺激SMMC7721细胞对葡萄糖的吸收
- Author:
Guoguang WANG
;
Haifeng DUAN
;
Genbao ZHANG
;
Zuze WU
- Publication Type:Journal Article
- Keywords:
Glucose;
Protein kinase B;
Sulfonylurea;
SMMC7721 cells
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the effects of the new drug of sulfonylurea(1-{4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]-phenylsulfonyl}-3-(1,4-tetramethylene)-urea,BGW) on the glucose uptake and the activation of Akt/PKB in SMMC7721 cells.METHODS:Cultured SMMC7721 cells were divided into control group,glibenclamide group,insulin group,BGW group and BGW+insulin group.Scintillation was used to detect the glucose uptake in SMM7721 cells.The activation of Akt/PKB was tested by Western blotting.RESULTS:Compared to control cells,gibenclamide,insulin,BGW and BGW+insulin significantly increased the glucose uptake(P
