Effect of tumor suppressor phosphatase and tensin homology deleted in chromosome 10 on renal interstitial fibrosis in IgA nephropathy
- VernacularTitle:IgA肾病PTEN表达及其对肾间质纤维化的影响
- Author:
Kun ZHANG
;
Shuxia FU
;
Huibin TAN
;
Lin YANG
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis,IgA;
Phosphatase and tensin homology deleted on chromosome 10;
Renal fibrosis;
Transforming growth factor beta;
?-smooth muscle actin
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the potential correlation between the expression of phosphatase and tensin homology deleted on chromosome 10(PTEN) and RIF in IgA nephropathy.METHODS:Forty-seven patients diagnosed as primary IgA nephropathy by renal histology were involved.10 specimens from normal renal tissue of renal carcinoma served as control group.Tubulointerstitial lesion(TIL) was classified by using Katafuchi scale,including no TIL(group I),mild TIL(group II),moderate TIL(group III),severe TIL(group IV).The expressions of PTEN,TGF-?1,?-SMA and ColⅢ in renal tissue were detected by immunohistochemistry.PTEN mRNA was detected by in situ hybridization.RESULTS:Renal tissues from renal biopsy showed abundant expressions of PTEN and PTEN mRNA in endochylema of renal tubular epithelial cells,and negligible expression in glomeruli.With the progress of TIF in IgA nephropathy,the expressions of PTEN and PTEN mRNA decreased gradually(P
