Construction of evolutionary tree model for esophageal carcinogenesis based on comparative genome hybridization data
- VernacularTitle:基于食管癌比较基因组杂交资料构建其进化树模型
- Author:
Tengfei LIU
;
Zhongxi HUANG
;
Zhihua YIN
;
Kaitai YAO
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Comparative genomic hybridization;
Tree model
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:Based on comparative genomic hybridization(CGH) data,to construct tree model of esophageal carcinoma and to explore mechanism of multigene involved,multistep development and multipathway progression during esophageal carcinogenesis.METHODS:Using the software developed by Desper et al,tree models of esophageal carcinoma were constructed according to the CGH data of 78 esophageal carcinoma patients.RESULTS:Tree models for esophageal carcinoma suggested that there were-4p,-9p,-18q,+7p,+8q,+17p,+17q,+20p,+20q nine nonrandom genetic events,and +7p、+8q and +20q might be important early events in esophageal carcinogenesis,indicating that there might be cancer-related genes in these chromosomal arms.CONCLUSION:Tree models based on CGH data of esophageal carcinoma imply the process of multigene involved,multistep and multipathway progression.The tree models also give the direction to search for esophageal cancer-related genes.
