Progress of silicon dioxiode induces liver cancer periphery fibrosis in experimental research
- VernacularTitle:二氧化硅诱导肝癌周围肝纤维化的实验研究进展
- Author:
Chaoyuan LUO
;
Haiping JIANG
;
Haiwei ZHANG
- Publication Type:Journal Article
- Keywords:
Silicon dioxiode;
Liver neoplasms;
Fibrosis;
Free radicals;
Cytokines;
Apoptosis
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Therapeutic efficiency of advanced stage liver cancer is insufficiency,which has become the hot spot of research.Clinical observation found that prognosis of liver cancer with integrity amicula was better.It is generally accepted that silicon dioxiode(SiO2) can induce pulmonary fibrosis,resulting in the formation of pneumosilicosis.Use of SiO2 as embolism material induces hepatic fibrosis and forms the fibrosis amicula around the liver carcinoma,and then restrains the recurrence and metabasis of liver cancer,which has been turned into one of the aspect of liver carcinoma therapy.The possible mechanisms of inducing hepatic fibrosis by SiO2 are peroxidative damage by free radical,releasing of active cytokines,or inducing cell apoptosis and the activation of HSC etc.
