Expressions and significance of survivin and Ki-67 in breast cancer tissues after neoadjuvant chemotherapy
- VernacularTitle:新辅助化疗后乳腺癌组织中survivin和Ki-67的表达及意义
- Author:
Qi CHEN
;
Yumin YAO
;
Ying ZHANG
;
Junlong XU
- Publication Type:Journal Article
- Keywords:
Breast Neoplasm/ drug ther;
Neo-adjuvant Chemotherapy;
survivin;
Ki-67;
Prognosis
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of survivin and Ki-67 in breast cancer tissues after neo-adjuvant chemotherapy and their clinical significance.Methods The expressions of survivin and Ki-67 in 60 cases of breast cancer with neo-adjuvant chemotherapy(NACT) with CTF regimen and 60 cases without NACT were detected by SABC immunohistochemical technique.ResultsThe positive rates of survivin(36.7%)and Ki-67(38.3%) in neo-adjuvant chemotherapy group were significantly lower than those in control group(71.7%,61.7%)(P0.05).ConclusionsThe therapeutic effect of neo-adjuvant chemotherapy with CTF regimen can increase the remission rate of breast cancer.Neo-adjuvant chemotherapy could inhibit the expression of survivin protein,and thus further inhibit proliferation of tumor cell.
