Research on correlation factors of breast cancer stem cell and breast cancer metastasis
- VernacularTitle:乳腺癌干细胞与乳腺癌转移相关因素的研究
- Author:
Guohua YANG
;
Xiaogeng CHEN
- Publication Type:Journal Article
- Keywords:
Breast Neoplasms/ pathol;
Stem Cell;
Neoplasm Metastasis
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression of VEGF,MMP-1,and CXCR4 in breast cancer stem cells and its significance.Methods Flow cytometry was employed to separate breast cancer stem cells from MCF-7 cell.Then the expression of VEGF,MMP-1,and CXCR4 was detected by PCR in different subsets of cells.ResultsCompared with the non-stem cells of breast cancer,the expression of VEGF,MMP-1,and CXCR4 in breast cancer stem cells was significantly higher,but the expression of MMP-1 was not different.ConclusionsThe breast cancer stem cells could achieve increased metastasis ability by enhanced expression of VEGF and CXCR4,which are the key factors in metastasis of breast cancer.
