Role of the coagulation and fibrinolysis in acute lung injury
- VernacularTitle:凝血和纤溶失衡在急性肺损伤中的作用
- Author:
Yanqin DONG
;
Jian LI
;
Xuan ZHANG
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
Respiratory distress syndrome;
Tissue factor;
Protein C;
Plasminogen activator inhibitor 1
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury(ALI) and acute respiratory distress syndrome(ARDS) are common,life-threatening causes of acute respiratory failure that arise from a variety of local and systemic insults.The pathogenesis of ALI/ARDS is complicated and not yet completely interpreted today.The role of altered coagulation and fibrinolysis in the pathogenesis of ALI/ARDS has been investigated.This review will summarize the current understanding of coagulation and fibrinolysis in human ALI/ARDS with emphasis on pathways that could be potential therapeutic targets.These pathways include the tissue factor pathway,the protein C pathway and modulation of fibrinolysis via plasminogen activator inhibitor-1.
