Determination of the Dissolution of Sitafloxacin Tablets
- VernacularTitle:西他沙星片溶出度测定
- Author:
Youliang WU
- Publication Type:Journal Article
- Keywords:
UV spectrophotometry;
Sitafloxacin tablets;
Dissolution
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish a method for the determination of the dissolution of sitafloxacin tablets.METHODS: The dissolution sitafloxacin tablets was determined by peddle method in accordance with Chinese Pharmacopeia(2005 edition) using 0.1 mol?L-1 HCl as the medium with the rotation speed set at 75 r?min-1.Sampling was carried at 30 min with its absorbability determined by UV spectrophotometry under a wavelength of 295 nm and its dissolution rate calculated.RESULTS: The linear range of sitafloxacin was 2～20 ?g?mL-1(r=0.999 6) with an average recovery rate of 99.95%(RSD=0.40%).The dissolution rates of 3 batches of samples were all above 90%.CONCLUSION: The method is simple,accurate with reliable results,and it is applicable for the determination the dissolution rate of sitafloxacin tablets.
