Content Determination of Preservative Ethylparaben in Hospital Preparation
- VernacularTitle:医院制剂中防腐剂羟苯乙酯的含量测定
- Author:
Yanlin JIAN
;
Guofang ZOU
- Publication Type:Journal Article
- Keywords:
Ethylparaben;
RP-HPLC;
Content determination;
Hospital preparation
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish a RP-HPLC method for the determination of preservative ethylparaben content in hospital preparation.METHODS: The determination was carried out on Spherisorb C18 column and the mobile phase consisted of acetonitrile-water(50∶50,V/V) at a flow rate of 1 mL?min-1.The column temperature was set at 35 ℃;the detection wavelength was set at 254 nm and the sample size was 20 ?L.RESULTS: The linear range of ethylparaben was 1.812 5～18.125 0 ?g?mL-1(r=0.999 9) with an average recovery rate of 99.92%.The intra-day RSD was less than 2.10% and inter-day RSD was less than 4.89%.CONCLUSION: The method is simple,rapid and accurate,and applicable for the determination of ethylparaben content in hospital preparation.
