Optimization of the Forming Technology of Tongtong Granules by Orthogonal Experiment
- VernacularTitle:正交试验优选酮通颗粒成型工艺
- Author:
Zhaorong SUN
;
Xiaming WU
- Publication Type:Journal Article
- Keywords:
Tongtong granules;
Forming technology;
Orthogonal experiment
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the forming technology of Tongtong granules.METHODS:The category and ratio of the adjuvants were optimized taking moisture absorption percentage as index;the forming technology of Tongtong granules was optimized by orthogonal experiment with forming rate and moisture absorption percentage as indexes and with the ratio of extract to adjuvant,the concentration and amount of ethanol as factors.RESULTS:The optimal ratio of lactose to dextrin was 3:2.The optimal forming technology was as follows:the ratio of extract to adjuvant was 1:2;70%alcohol was used as the wetting agent with its amount at 12%(mL?g~(-1)).The Tongtong granules mobility enjoyed good flowability with a critical relative humidity of about 70%.CONCLUTION:The forming technology is feasible,stable,reasonable and reproducible and it serves as theoretic basis for industrial production.
