Effects of Total Glucosides of Paeony on the Expression of CD4 + T Lymphocytes and IL - 6 in Rats with Chronic Abacterial Prostatitis
- VernacularTitle:白芍总苷对慢性非细菌性前列腺炎大鼠CD4+T淋巴细胞及IL-6的影响研究
- Author:
Chaodong LIU
;
Hongzhi WANG
;
Chao WEI
- Publication Type:Journal Article
- Keywords:
Prostatitis;
Total glucosides of paeony;
CD4+T lympholeukocyte;
lInterleukin-6
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of total glucosides of paeony(TGP) on the expressions of CD4+ T lymphocytes and IL- 6 in prostatic tissues of rats with chronic abacterial prostatitis(CAP) and to study its action mechanism on CAP.METHODS:36 SD rats were randomly divided into three groups:CAP control group(n = 12 rats),low dose CAP + TGP group(n = 12) and high dose CAP + TGP group(n = 12).The expressions of CD4+ T lympholeukocytes and IL- 6 in prostatic tissues of rats were detected by immunohistochemistry after medication were investigated,and the changes in histopathology of prostatic tissues.RESULTS:Significant inflammatory condition was noted in CAP control group;improvement of glandular structure and infiltration of small number of inflammatory cells were noted for low dose TGP group.In high dose TGP group,inflammation was abated markedly and there was diffused distribution of a few number of inflammatory cells. As compared with CAP group,the expressions of CD4+ T lymphocytes and IL 6 were down regulated significantly in both the high dose and low dose TGP groups(P
