Antagonistic Effect of Ziyin Xiehuo Recipe on Estrogen-like Activity of Environmental Endocrine Disruptors Exposed Rats
- VernacularTitle:滋阴泻火方对环境内分泌干扰物染毒大鼠拟雌激素活性的拮抗作用
- Author:
Yuanyuan KONG
;
Liewei ZHU
;
Depei CAI
- Publication Type:Journal Article
- Keywords:
Ziyin Xiehuo Recipe(ZYXHR,Recipe for nourishing kidney yin and purging ministerial fire);
Nonylphenol;
Bisphenol A;
Uterotrophic assay;
PCNA;
Chinese medicine therapy
- From:
Journal of Traditional Chinese Medicine
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the antagonistic effect of Ziyin Xiehuo Recipe(ZYXHR,Recipe for nourishing kidney yin and purging ministerial fire) on estrogen-like activity of environmental endocrine disruptors,nonylphenol(NP) and mixture of NP and bisphenol A(BPA). Methods Totally 30 three-week-old female SD rats were randomly divided into control group(fed with corn oil),exposed group A (feeding NP100 mg / kg ),exposed group B (feeding NP 50 mg/kg+ BPA 200 mg/kg ),treatment group A (NP 100 mg/kg + ZYXHR),treatment group B (NP 50 mg/kg+ BPA 200 mg/kg + ZYXHR). After 15 days of treatment,the uterine weight gain and PCNA protein expression were detected. Results As compared with those of the control group,Uterine wet weight,uterus organ coefficient,thickness of endometrium and smooth muscle,and the height of endometrial glands and glandular epithelium significantly increased in exposed group A and B (P
