The expression and efffects of RSpo1 and ?-catenin in intestinal epithelium with intestinal ischemia-reperfusion injury in mouse
- VernacularTitle:肠缺血再灌注损伤后RSpo1和?-catenin在肠上皮的表达及作用
- Author:
Gang YIN
;
Chengtang WU
;
Shangtong LEI
;
Yunxing WANG
- Publication Type:Journal Article
- Keywords:
Intestinal Ischemia-Reperfusion Injury;
R-Spondin1;
?-catenin;
Intestinal Epithelial Stem Cell
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and effects of RSp1 and ?-catenin in the intestinal epithelium with intestinal ischemia-reperfusion injury(IIRI)in of mouse.Methods Fifty healthy male kunming mice were randomly divided into control group(n=10)and experimental group(n=40).All mice in control group were only subjected to laparotomy,while the other mice underwent 20 minutes of intestinal mesenteric artery occlusion followed by 6 hours(group A),12 hours(group B),24 hours(group C)and 48 hours(group D)of reperfusion.RT-PCR was used to detect RSpo1 and ?-catenin in small intestine in intestinal ischemia-reperfusion groups and in control group.Results The villous heights of intestinal in experimental groups were significantly lower than that in control group(P
