Effects of Different Important Growth Factors in Diabetic Nephropathy
- VernacularTitle:几种重要生长因子在糖尿病肾病中的作用
- Author:
Rui YAN
;
Laixiang LIN
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Growth factor
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy is one of the most serious microvascular complications, which is related to many growth factors. Growth factors are a kind of cytokines that can stimulate cells to grow, which includes transforming growth factor-? (TGF-?), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), connective tissue growth factor (CTGF), and so on. Different growth factors can cause glomerular hypertrophy or proliferation, perinephric angiogenesis, tubulointerstitial fibrosis and the like respectively. To know the relationship between the growth factors and diabetic nephropathy could provide a prospective mean to reduce the diabetic mortality rate. This paper reviews the recent researches about the growth factors and diabetic nephropathy to provide a scientific basis for clinical treatment.
