Association of Polymorphism of Lipoprotein Lipase Gene with Type 2 Diabetes and the Lipids Spectrum in Uygurs
- VernacularTitle:脂蛋白脂酶基因HindⅢ酶切多态性与维吾尔族2型糖尿病及体内脂质谱的关联研究
- Author:
Hanqiu LI
;
Hui XIAO
;
Yueming ZHANG
- Publication Type:Journal Article
- Keywords:
LPL gene;
Uygur;
T2DM;
Gene polymorphism, TG
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of LPL gene polymorphism with type 2 diabetes and the lipids spectrum in Uygurs. Methods Based on the case-siblings control design, the lipid spectrum of Uygur were tested by Automatic biochemical analyzer and the polymorphism of LPL gene were analyzed by RLFP with Hind Ⅲ in 62 T2DM patients, 62 IGT patients and 124 normal controls of Uygurs. Results The genotype distribution and allele frequencies of LPL gene in three groups were not statistically significant. The average of TG in H+H+group, H-H-group and H+H-group were 2.26, 1.73 and 1.80 mmol/L; Compared with the three genotypes and lipid indicators, TG content of Mutant H +H + group were higher than that in other groups. Multi-factor Logistic regression analysis showed T2DM was closely related to TG (P=0.034)and waist circumference (P=0.001). Conclusion The relation between LPL gene polymorphism by Hind Ⅲ and the risk for T2DM in Xinjiang Uygur population are no statistical relevance, LPL gene mutations may be one of the factors causing elevated levels of plasma TG.
