Effects of OGP derivate H86A on Bone Metrology in Ovariectomized Rats
- VernacularTitle:成骨生长肽羧基端片段衍生物H86A对去卵巢大鼠骨计量学的影响
- Author:
Jing ZHANG
;
Ling CHEN
;
Mingcai QIU
- Publication Type:Journal Article
- Keywords:
Primary osteoporosis;
Community intervention;
Intervention pattern;
Effectiveness
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of OGP (10-14) and its derivate H86A on bone metrology in rats with ovariecto-my-reduced osteoporosis. Methods Thirty-two female Sprague-Dawley rats, three months old, were randomly divided into 4 groups. Rats in groups 1 to 3 were bilaterally ovariectomized(OVX) and the others in group 4 were sham-operated. After the operation, rats in group 1 and group 2 were received derivate of OGP(10-14) H86A daily at different concentration. Group 3 were given placebo. Rats were killed after 12 weeks. Left tibias were disconnected and made into non-decalcified bone slice, and then they were detected and analyzed on indexes which were relative with bone metrology. Results Compared with Group 3, no other indexes except OV/BV was obviously different in rats with high dose H86A (P
