Dexamethasone Against Temozolomide's Cyto-inhibition on Gliocytoma Cells:An Empirical Study
- VernacularTitle:地塞米松拮抗替莫唑胺抑制胶质瘤细胞生长的体外试验
- Author:
Li ZHAO
- Publication Type:Journal Article
- Keywords:
Temozolomide;
Dexamethasone;
Gliocytoma cell;
Cell cycle
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the effect of temozolomide(TMZ)in combination with dexamethasone(DXM)on the proliferation of human gliocytoma U251 cells in vitro.METHODS:Human U251 cells were assigned to 1 of the 3 groups: TMZ(10,25,50,100,200,400?mol?L~(-1),respectively)alone or in combination with 40?mol?L~(-1)DXM(TMZ+DXM group)or control group(none drug).After treatment for 72 hours,the cell morphology,cell inhibition ratio,cell cycle and the apoptotic rate were detected.RESULTS:When TMZ concentration was greater than 100?mol?L~(-1)the cell inhibition ratio was higher in TMZ-treated group than in TMZ+DXM-treated group(P
