Effects of Erythromycin on Voltage-dependent Potassium Current in Hippocampal Neurons of Mice
- VernacularTitle:红霉素对小鼠海马神经元电压依赖性钾电流的影响
- Author:
Yong LU
;
Xiaoxia KONG
- Publication Type:Journal Article
- Keywords:
Erythromycin;
Mice;
Hippocampal neurons;
Whole-cell patch clamp technique;
Voltage-dependent K~+ current
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of erythromycin on the voltage-dependent K~+ current in hippocampal neurons of mice.METHODS:Isolation of mice's hippocammal neurons cells and whole-cell patch-clamp techniques were applied to study the change of voltage-dependent K~+ current of hippocampal neurons and the current-voltage curves in mice before and after treatment with erythromycin.RESULTS:Erythromycin inhibited the voltage-dependent K~+ current of mice's hippocampal neurons,and it down-regulated the peak current from(810.67?250.86)pA to(529.96?171.83)pA(P
