Biological Property and Tissue Distribution of Doxorubicin Albumin Microspheres in Rats
- VernacularTitle:多柔比星白蛋白微球的生物性质及其在大鼠体内的分布
- Author:
Yanqiu ZHANG
- Publication Type:Journal Article
- Keywords:
Doxorubicin albumin microspheres;
Biological property;
Rat;
Tissue distribution
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the biological property of doxorubicin albumin microspheres(DR-HAS-MS) and its tissue distribution in the rats.METHODS:Pancreatin degradation method was applied to determine the biodegradation property of DR-HAS-MS as well as the correlation between the cross linking agent concentration and the degradation time and between the setting time and the degradation time.The dialysis method was applied to study the in vitro drug dissolution/ release characteristics of DR-HAS-MS vs.DR solution.DR concentrations in different tissue of rats at different time following intravenous DR HAS-MS vs.DR solution(at a dose of 2.5 mg?kg~(-1))were determined.RESULTS:The degra dation time increased with the increase of cross linking agent concentration and cross - link time.The optimal setting time was 90 min.Within 6 hours the dissolution ratio of DR from DR solution was 100%,while the releasing ratio of DR from DRHAS -MS suspension was only 80%within 168 hours;DR concentrations in the liver and the spleen in the DR HAS-MS group were significantly higher than in DR solution group(P
