Protective Effect of Trimetazidine Against Coxsackie Virus B3-induced Myocarditis in Mice
- VernacularTitle:曲美他嗪对柯萨奇B3病毒致小鼠病毒性心肌炎的保护作用
- Author:
Lin ZHENG
- Publication Type:Journal Article
- Keywords:
Trimetazidine;
Viral myocarditis;
Mice;
Cytokines
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the protective effect of trimetazidine against myocarditis induced by coxsackie virus B3(CVB3)in mice.METHODS:Myocarditis in Balb/c mice was induced by CVB3.Then the mice were randomized to blank group,myocarditis control group and trimetazidine(low,medium,and high concentrations)treatment groups for 7 days.Serum levels of IFN-?,TNF-?,IL-10 and IL-12 were determined on mice,meanwhile the virus titer of the myocardium, pathologic change,MDA concentration,SOD and CAT activities were detected.RESULTS:As compared with myocarditis control group,in groups treated with trimetazidine,serum levels of IFN-?,IL-10 and IL-12 increased significantly, but the change in serum TNF-?level was nonsignificant,the virus titer of myocardium decreased and pathological lesions of myocardium were ameliorated,the MDA concentration decreased,but SOD and CAT activities were up-regulated (P
