Mechanism of Compound Geshanxiao Granules for Chronic Atrophic Gastritis
- VernacularTitle:复方隔山消颗粒用于大鼠慢性萎缩性胃炎的机制研究
- Author:
Wensheng LI
- Publication Type:Journal Article
- Keywords:
Compound geshanxiao granules;
Chronic atrophic gastritis;
Gastrin;
Motilin;
p53 gene;
Proliferating cell nuclear antigen
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE:To study the action mechanism of Compound geshanxiao granules for chronic atrophic gastritis. METHODS: Experimental chronic atrophic gastritis model was established in rats by intragastric administration of hot saline water, after intragastric with Compound geshanxiao granules, the serum level of gastrin(GAS) and plasma level of motilin(MTL) in rats were determined, and the expressions of rat gastric mucous membrane p53 genes and the proliferating cell nuclear antigen(PCNA) were detected by immunohistochemistry method. RESULTS: Serum GAS level and plasma MTL level decreased markedly in chronic atrophic gastritis model rats. After treatment with Compound geshanxiao granules, serum GAS level and plasma MTL level increased markedly, while the positive expression rates of p53 genes and PCNA labeling index in gastric mucous membrane cells decreased significantly. CONCLUSION: The action mechanism of Compound geshanxiao granules for chronic atrophic gastritis might be achieved by promoting secretions of gastrin and motilin and inhibiting the positive expressions of p53 genes and PCNA proteins.
