Effect of Ultramicronization on Dissolution of Atractylenolide from Atractylodes Macrocephala
- VernacularTitle:超微粉碎对白术中内酯成分体外溶出的影响
- Author:
Zhongming YU
;
Shiwen DAI
;
Dan SHOU
;
Jianming ZHANG
- Publication Type:Journal Article
- Keywords:
Atractylodes macrocephala;
Ultramicronization;
Atractylenolide Ⅲ;
Atractylenolide Ⅰ;
Particle size analysis;
HPLC
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the change in grain size and in vitro dissolution ratio of Atractylodes macrocephala after ultramicronization. METHODS: The particle size before and after ultramicronization was analyzed using particle size analyzer. The content of the sample was determined by HPLC using atractylenolide Ⅲ and atractylenolide Ⅰ as indexes to reflect the dissolution ratio. RESULTS: After ultramicronization, the particle size of the sample became thinner obviously, about 30% that of the common fine powder, and the content increased by 27% as compared with the common fine powder. CONCLUSION: The ultramicronization can significantly decrease the particle size, increase specific surface area and contribute to the dissolution of atractylenolide Ⅲ and atractylenolide I from Atractylodes macrocephala.
