Inhibitory effect of RNAi on the expression of AQP1 and the migration ability of Hep-2
- VernacularTitle:RNA干扰抑制AQP1表达对Hep-2细胞迁移能力影响的实验
- Author:
Guimei GUAN
;
Zhen DONG
;
Xiaodan JIANG
- Publication Type:Journal Article
- Keywords:
Laryngeal Neoplasms;
Aquaporin 1;
RNA Interference;
Cell Movement
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). The movement and invasion ability were evidently inhibited in AQP1-siRNA groups compared with those in blank control groups and negtive control groups [(36? 3), (23?4)/HP vs(70?5),(65?4)/HP and(72 ?4),(69?4)/HP, respectively, P0.05).CONCLUSION The knock down of AQP1 by RNAi have no effect on the adhesion ability of Hep-2 cells, whereas could prevent the movement and invasion ability of laryngocarcinoma cells, which may be related with the metastasis of laryngeal carcinoma.
