The expression of COX-2 and VEGF in laryngeal carcinoma tissue and its clinical significance
- VernacularTitle:环氧化酶-2和血管内皮生长因子在喉癌中的表达及临床意义
- Author:
Zuyao CHEN
;
Ling YU
;
Zhuoping LIANG
;
Wenjun LIU
;
Wanrong LI
;
Gang QIN
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase2;
Vascular Endothelial Growth Factors;
Laryngeal Neoplasms;
Carcinoma, Squamous cell;
Neovascularization, Physiologic
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the expression of Cyclooxygenase-2(COX-2)andVascular endothelial growth factor(VEGF)in laryngeal carcinoma tissue and its clinical significance. METHODS Sixty-five samples of laryngeal carcinoma and thirty-four biopsies of adjacent noncancerous tissue were immunohistochemically examined for expression of COX-2 and VEGF, whose relationship with clinicopathological parameters was also analysied. RESULTS Percentages of COX-2 and VEGF expression in laryngeal carcinoma tissue were 63.08% and 70.77% respectively, which were higher than those in adjacent noncancerous tissue(P
