Efficacy of Mycobacterium Bovis in Combination with Antituberculosis Drugs for Initially Treated Smear Positive Pulmonary Tuberculosis(TB)in Senile Patients
- VernacularTitle:母牛分枝杆菌联合抗结核药治疗老年初治涂阳肺结核的疗效评价
- Author:
Bo CHEN
;
Weihong GAO
- Publication Type:Journal Article
- Keywords:
Pulmonary tuberculosis;
Antituberculosis drugs;
Mycobacterium bovis;
Senile patients
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the clinical efficacy and adverse effects of mycobacterium bovis in combination with antituberculosis drugs for initially treated smear positive pulmonary tuberculosis(TB)in senile patients.METHODS:A total of 121 initially treated smear positive TB cases were assigned to receive 2HReZE/4HRe alone(control group,n=61)or in combination with Mycobacterium bovis(22.5 ?g,once in two weeks for 6 months started at the end of the second week,treatment group,n=60).RESULTS:At the end of the first and second month since treatment,the sputum negative conversion rates showed significant differences between the treatment group and the control group(63.9% and 86.9% respectively in treatment group vs.30.0% and 58.3%,respectively in control group)(P0.05).CONCLUSION:As compared with antituberculosis drugs alone,the concomitant use of mycobacterium bovis and antituberculosis drugs shortened the time for the sputum negative conversion,focal absorption on X-ray chest film and clinical symptom improvement in initially treated smear positive senile TB patients,and mycobacterium bovis is a satisfactory immunotherapeutic agent for TB and it can be used in combination with antituberculosis drugs for smear positive senile TB patients.
