Inhibitory Effect of Hydrocortisone on Fentanyl-induced Cough Reflex:A Clinical Study
- VernacularTitle:氢化可的松抑制芬太尼诱发咳嗽反射的临床研究
- Author:
Xiaoqiang LI
- Publication Type:Journal Article
- Keywords:
Fentanyl;
Cough reflex;
Hydrocortisone
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the inhibitory effect of hydrocortisone on fentanyl-induced cough reflex(FIC).METHODS:160 patients undergoing scheduled operation on abdominal region were randomized to receive Normal Saline 100 mL(Group Ⅰ)or hydrocortisone 100 mg added to 100 mL Normal Saline iv gtt(Group Ⅱ);15 minutes later,both groups were injected intravenously with fentanyl(2 ?g?kg-1)with injection time of 2 seconds.The frequency and the onset time of cough as well as the adverse drug reactions in the two groups were observed.RESULTS:The FIC incidence in Group Ⅱ was significantly lower than in Group Ⅰ(10% vs.35%),showing significant differences between the two groups(P
