Adverse Drug Reactions Induced by Antitumor Drugs:Literature Analysis of 112 Cases
- VernacularTitle:112例抗肿瘤药致不良反应文献分析
- Author:
Chunshuang DU
- Publication Type:Journal Article
- Keywords:
Antitumor drugs;
Adverse drug reaction;
Literature analysis
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the characteristics and genernal patterns of adverse drug reactions(ADR)induced by antitumor drugs.METHODS:112 ADR cases induced by antitumor drugs included in CNKI from 2003 to 2007 were analyzed statistically in respect of patients' age and sex,primary diseases,drug categories,organs and systems involved and the clinical manifestations etc.RESULTS:Of the total 112 cases,patients aged from 51 to 60 years showed the highest incidence of ADR,accouting for 31.3%,and Platinum antitumor drugs showed the highest incidence of ADR,accounting for 36.6%.The most common presentation of ADR was lesion of nervers system(41.1%),followed by lesions of respirotory system(32.1%)and skin and the appendants(28.6%).CONCLUSION:Awareness on the reporting of ADR induced by antitumor drugs should be strengthened and the characteristics of the ADR should be analyzed to ensure clinical safe and rational use of antitumor drugs and avoid or reduce the incidence of ADR.
