An Exploratory Study Mitochondrial DNA Deletion and its Relationship to Noise-Induced Hearing Loss
- VernacularTitle:职业性噪声性聋与mtDNA缺失关系的探讨
- Author:
Yue WANG
;
Jiaying ZHANG
;
Yudan HAN
;
Yulan LI
- Publication Type:Journal Article
- Keywords:
Noise,occupational;
Hearing loss,noise-induced;
Mitochondrial(DNA);
Gene deletion
- From:
Journal of Audiology and Speech Pathology
1998;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the possible effects of mitochondrial DNA mutation on noise-induced hearing loss.Methods 265 young workers with noise exposure were examined.The average pure tone thresholds at 500,1 000,and 2 000 Hz for 25 voluntary persons were noise-induced hearing loss by nature and selected as the study group.27 voluntary persons with no speech frequency hearing loss were chosen as the control group.DNA was extracted from peripheral blood leukocytes.Polymerase chain reaction(PCR) was used to detect the mtDNA4977 deletion in both groups.Results The detection rate of mtDNA4977 deletion in the study group was 20%(5/25) and it was 0(0/27) for the control group.Conclusion MtDNA4977 deletion in the study group was significantly higher than that of the control group,indicating that mtDNA4977 deletion may play an important role in the development of noise-induced hearing loss.
