Study of the Antagonist Effects of Sodium Salicylate on the Cisplatin Induced Hearing Impairment in Guinea Pigs
- VernacularTitle:水杨酸钠对顺铂致豚鼠听损伤的拮抗作用
- Author:
Xueling WANG
;
Zedeng YIN
;
Dan LAI
;
Wanrong LI
- Publication Type:Journal Article
- Keywords:
Cisplatin(CDDP);
Sodium salicylate(NaSA);
Auditory brainstem response(ABR);
Distortion product otoacoustic emission(DPOAE)
- From:
Journal of Audiology and Speech Pathology
1998;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antagonist effects of sodium salicylate(NaSA) on the cisplatin(CDDP) induced hearing impairment in guinea pigs.Methods 60 guinea pigs were randomly divided into four groups: ①CDDP +NaSA(50 mg/kg) group,②CDDP +NaSA(100 mg/kg) group,③CDDP +NaSA(150 mg/kg) group and ④CDDP +NS(normal saline) control group.Auditory brainstem response(ABR) and distortion product otoacoustic emission(DPOAE) were used to evaluate their effects on hearing threshold and DPOAE amplitudes.Results The ABR responses of groupsⅠ,Ⅱ and Ⅲ were significantly lower than in the control group(P0.05).The ABR responses for group Ⅰ were significantly higher than group Ⅲ(P
