Significance of NF-?B in immunopathogenesis of Graves disease
- VernacularTitle:NF-?B在Graves病免疫病理机制中的意义
- Author:
Xun MIN
;
Daixiong CHEN
;
Yonglun WANG
;
Ning FANG
;
Weihong WAN
;
Jinwei LIU
;
Yu XIAO
;
Zhenzhong ZHOU
- Publication Type:Journal Article
- Keywords:
Graves' disease;
NF-kappa B;
Cytokines
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the activity of NF-?B in peripheral blood mononuclear cells (PBMCs) from patients with Graves disease (GD) and the significance in immunopathogenesis of GD.METHODS:Peripheral blood was collected from 22 untreated GD,20 treated GD with tapazole more than 1 year,and 25 healthy volunteers. PBMCs were isolated from the blood by histopaque-1077 density-gradient centrifugation. The activity of NF-?B in PBMCs was analyzed using gel electrophoretic mobility shift assay (EMSA). The contents of IL-1?,IL-6 and TNF-? were tested by radioimmunoassay.RESULTS:The activity of NF-?B in PBMCs of untreated GD group was increased remarkably,compared with that in the treated group and control (P
