Effect of transketolase-like protein 1 on proliferation of human nasopharyngeal carcinoma cells
- VernacularTitle:转酮酶样蛋白1在人类鼻咽癌细胞生长增殖中的作用
- Author:
Song ZHANG
;
Juhong YANG
;
Weijia KONG
;
Yu SUN
- Publication Type:Journal Article
- Keywords:
Transketolase-like protein 1;
Nasopharyngeal neoplasms;
CNE cell line;
Cell cycle
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). However,the expression level of TKTL1 gene was significantly downregulated in the CNE cells transfected with siRNA TKTL1 construct compared with the cells transfected with control vector. Cancer cells were arrested in G0/G1 phase,and cancer cell proliferation was significantly inhibited in the CNE cells transfected with siRNA TKTL1 construct. CONCLUSION:TKTL1 plays an important role in the total transketolase activity and cell proliferation of human nasopharyngeal carcinoma. TKTL1 may be considered as a potential target for novel anti-cancer therapy.
