Effects of Deproteinised Calf Blood Injection on Insulin Resistance in Model Rat with Type 2 Diabetes Mellitus Complicating Cerebral Infarction
- VernacularTitle:小牛血清去蛋白注射液对2型糖尿病合并脑梗死模型大鼠胰岛素抵抗的影响
- Author:
Jinyan LI
;
Hongru YU
- Publication Type:Journal Article
- Keywords:
Deproteinised calf blood injection;
Type 2 diabetes mellitus;
Cerebral infarction;
Rat;
Insulin resistance;
Blood glucose;
Serum lipid metabolism
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effects of deproteinised calf blood injection(DCBI) on blood glucose and lipid metabolism and its ameliorating effect on insulin resistance(IR) in model rats with type 2 diabetes mellitus(T2DM) complicating cerebral infarction.METHODS: Rats were fed with high fat and high glucose diet and injected with streptozotocin(STZ) vial caudal vein to duplicate T2DM model,followed by duplication of middle cerebral artery occlusion(MCAO) rat model.Then the rats were assigned to model group,sham-operated group,DCBI low and high dosage group(30,60 mg? kg-1?d-1 intraperitoneally),and rosiglitazone control group;meanwhile,another normal group was established.After receiving the corresponding drugs for 5 weeks for each group,fasting blood glucose(FBG),serum insulin(FINS) and sugar tolerance(OGTT) were determined,and levels of insulin resistance index(IRI),insulin sensitivity index(ISI),total cholesterol(TC),triglyeride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),and free fatty acid(NEFA) levels were computed.RESULTS: As compared with model group,in DCBI-treated model rats with T2DM complicating cerebral infarction,FBG were significantly decreased,sugar tolerance increased significantly(P0.05);IR was ameliorated(P
