Preparation and Quality Control of Thermo-sensitive Ornidazole Hydrogel
- VernacularTitle:奥硝唑温敏性水凝胶的制备及质量控制
- Author:
Xianling SHEN
;
Chuanxin XU
;
Feng XIAO
- Publication Type:Journal Article
- Keywords:
Ornidazole;
Thermo-sensitive hydrogel;
Poloxamer;
Preparation;
Quality control
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare thermo-sensitive ornidazole hydrogel and establish its quality control method.METHODS: Thermo-sensitive ornidazole hydrogel was prepared with ornidazole as chief constituent using poloxamer 407 and poloxamer 188 as base.The content of ornidazole in the hydrogel was determined by ultraviolet spectrophotometry.RESULTS: The preparation was white or yellowish semisolid gel,and its test results were up to the related standard specified in Chinese Pharmacopeia(2005 Edition).The linear range of ornidazole was 3.98～43.77 mg?L-1(r=0.999 8),and its mean recovery was 98.52%(RSD=1.1%).CONCLUSION: The preparation is simple and feasible in preparation process,and the quality of the preparation is stable and controllable.
