Effects of Carthamus Tinctorius on Oxidative Stress of Kidney in Rats with Diabetic Nephropathy
- VernacularTitle:红花对2型糖尿病大鼠肾脏氧化应激反应的影响
- Author:
Shenwei LIU
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Oxidative stress;
Carthamus tinctorius
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of Carthamus tinctorius on oxidative stress of kidney in rats with type 2 diabetes mellitus. METHODS:Type 2 diabetes mellitus rat model was developed successfully by unilateral nephrectomy and giving high lipid and high glucose diet and low dose streptozotocin (STZ). Then the model rats were randomly divided into four groups:control group,model group,low-dose and high-dose Carthamus tinctorius groups. After treatment for 12 weeks,biochemical indicators,urinary albumin excretion rate (UAER),the activities of superoxide dismutase (SOD) and Glutathione peroxidase (GSH-PX) and the content of malonaldehyde (MDA) in the renal tissue,and the mRNA gene expressions of both P22phox and P47phox in renal cortex were measured. RESULTS:Compare with model group,Carthamus tinctorius-treated groups (high-dose and low-dose) showed no significant difference in blood glucose level,but much significant decrease in levels of serum creatinine,urea nitrogen and UARE,significant increase in SOD and GSH-PX activities,much significant decrease in MDA content and significant downregulation of mRNA expressions of both P22phox and P47phox. CONCLUSION:Carthamus tinctorius-treatment can mitigate the oxidative stress of renal cortex to play protective effect on kidney and delay the development of diabetic nephropathy.
