Effects of Xingnaojing Injection on the Expressions of the Protein of IL-1? and the mRNA in Rats with Intracerebral Hemorrhage
- VernacularTitle:醒脑静注射液对脑出血大鼠IL-1?蛋白及其mRNA表达的影响
- Author:
Fang LIU
;
Guizhi YANG
- Publication Type:Journal Article
- Keywords:
Xingnaojing injection;
Rats with intracerebral hemorrhage;
Cerebral edema;
IL-1?
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of Xingnaojing injection on the expressions of both the protein of IL-1? and the mRNA in the experiment intracerebral hemorrhage rats.METHODS:Referenced by Zou's method and Rosengerg method,rat intracerebral hemorrage model was established and the model rats were then divided into normal group,model group and Xingnaojing group.The pathological changes in all the groups were observed and the expressions of the protein of IL-1? and the mRNA were detected after medication.RESULTS:In Xingnaojing group as compared with model group,the cells arranged regularly,the edema degree was lessened,the inflammatory cells were less;the disorganization of plastiosome was less severe,synaptic structure was clearer.The expressions of both the protein of IL-1? and the mRNA were all lower than in the model group.CONCLUSION:Xingnaojing injection can relieve the cerebral edema and inhibit the expression of IL-1? of the brain tissue surrounding the hematoma in intracerebral hemorrhage rats.
