Effects of Artesunate on Free Ca~(2+) Concentration in Human Prostatic Cancer PC-3 Cells
- VernacularTitle:青蒿琥酯对人前列腺癌PC-3细胞内游离Ca~(2+)的影响
- Author:
Changcheng ZHANG
;
Xiaopeng ZHANG
- Publication Type:Journal Article
- Keywords:
Artesunate (ART);
Prostatic cancer;
Intracellular free Ca2+ ([Ca2+]i)
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of artesunate(ART) on free Ca2+ concentration([Ca2+]i) in human prostatic cancer PC-3 cells.METHODS:PC-3 cells were treated with ART and labeled using Ca2+ fluorescent probe Fluo-3/AM,and the change of[Ca2+]i was evaluated by confocal laser scanning microscopy.RESULTS:After PC-3 cells were exposed to artesunate,the intracellular [Ca2+]i concentration increased significantly at 0～0.5 h,maintained at a high level at 0.5～1 h,but decreased to the level of the initial at 4～24 h. CONCLUSION:ART can induce the marked sustained increase of[Ca2+]i and [Ca2+]i might play an important role in ART-induced apoptosis of human PC-3 cells.
