Decoction for Longdan Xiegan Tang vs. Longdan Xiegan Pills in Equivalence
- VernacularTitle:龙胆泻肝汤煎剂与丸剂等量性研究
- Author:
Ruixin LIU
- Publication Type:Journal Article
- Keywords:
Longdan xiegan tang;
Longdan xiegan pills;
Equivalence;
Gentiopicroside;
Jasminoidin
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the equivalence of preparations of traditional Chinese medicines with decoction and pill as the representative dosage forms so as to lay a foundation for the evaluation of equivalence.METHODS:Taking the contents of gentiopicroside and geniposide and water soluble extractive as indexes to investigate the equivalence between decoction for Longdan xiegan tang and Longdan xiegan pills.RESULTS:Evaluated by the indexes of contents of gentiopicroside and geniposide,the current daily oral dosage of the decoction was 6.39 times superior to the pill;taking water soluble extractive as index,the decoction was 4.02 times superior to the pill.CONCLUSION:To be equivalent to the decoction,the current daily oral dosage of the pill should be increased appropriately.The degree of increase should be based on the final results of pharmacological and clinical studies.
