Expression and their significance of c-Met and TIMP-2 in laryngeal squamous cell carcinoma
- VernacularTitle:c-Met和TIMP-2在喉癌中的表达及其意义
- Author:
Juan ZHENG
;
Wanrong LI
- Publication Type:Journal Article
- Keywords:
Prto-Oncogene Protein c-met;
Tissue Inhibitor of Metalloproteinases;
Laryngeal Neoplasms;
Carcinoma,Squamous Cell;
Immunohistochemis
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the expression of c-Met,TIMP-2 in laryngeal squamous cell carcinoma and to explore the function and relationship of c-Met,TIMP-2 in the invasion and metastasis of laryngeal squamous cell carcinoma. METHODS Immunohistochemical method(SP) was used to detect the expression of c-Met,TIMP-2 in 41 laryngeal squamous cell carcinoma specimens and 15 specimens adjacent to the tumors.RESULTS The positive rate of c-Met and TIMP-2 in laryngeal squamous cell carcinoma specimens was 56.1% (23/41)and 63.4%(26/41)respectively.The positive rate of c-Met in tissues adjacent to tumors was 13.3%(2/15).No positive expression of TIMP-2 was found in tissues adjacent to tumors.CONCLUSION The expression of c-Met showed a positive correlation with histological differentiation and cervical lymph node metastasis and TIMP-2 showed a positive correlation with cervical lymph node metastasis in laryngeal squamous cell carcinoma.There was no significant relation between the expression of c-Met and TIMP-2 in laryngeal squamous cell carcinoma.
