Changes of the Resistance of Common Pathogenic Bacteria Isolated During the Past 5 Consecutive Years in Our Hospital to Quinolones
- VernacularTitle:我院连续5年临床常见病原菌对喹诺酮类药物的耐药变迁
- Author:
Jiancheng XU
;
Qi ZHOU
;
Shaohui LIU
;
Jing HUANG
- Publication Type:Journal Article
- Keywords:
Quinolones;
Methicillin-resistant Staphylococcus aureus;
Methicillin-resistant coagulase negative Staphylococcus;
Antimicrobial susceptibility test;
Drug monitoring
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the change of the resistance of common pathogenic bacteria isolated in the First Clinical Hospital of Jilin University during the past 5 years to quinolones.METHODS: Disk diffusion test was used to study the susceptibility test,with the results evaluated based on US Clinical and Laboratory Standards Institute(CLSI).WHONET-5 software was used to analyze the drug resistance data.RESULTS: During 2003～2007,the detection rates of extended spectrum beta-lactamases(ESBLs)-producing Escherichia coli and Klebsiella.spp were 43.6%～60.1% and 51.0%～65.1%,respectively;the detection rates of methicillin-resistant Staphylococcus aureus(MRSA) and methicillin-resistant coagulase negative Staphylococcus(MRSCN) were 50.8%～83.3% and 80.0%～81.5%,respectively;the resistance of common pathogenic bacteria to quinolones showed an increasing tendency,much as in MRSA,MRSCN,feces enterococci,Enterococcus faecalis,and Escherichia coli.CONCLUSION: Monitoring of the resistance of common pathogenic bacteria to quinolones should be strengthened.The change of the antimicrobial resistance should be investigated in order to direct rational drug use in the clinic and prevent the propagation of drug-resistant strains.
