Effect of Reinforcing Kidney and Activating Blood Therapy on Apoptosis of Rat Models with Endometriosis
- VernacularTitle:补肾活血法对子宫内膜异位症模型大鼠细胞凋亡的影响
- Author:
Hua ZHOU
;
Cong QI
- Publication Type:Journal Article
- Keywords:
Reinforcing kidney and activating blood therapy;
Endometriosis;
bcl-2 and bax;
TCM therapy
- From:
Journal of Traditional Chinese Medicine
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of reinforcing kidney and activating blood therapy for the apoptosis of endometriosis.Methods Female SD rats aged 8~12weeks were grouped as model group,western medicine group,Chinese medicine group and integrated Chinese and western medicine group,with 15 in each group.The light microscope,electron microscope,TUNEL method,and immunohistochemical method were adopted to observe the pathomorphology,positive rate of apoptotic cells and the positive expression of apoptosis-regulating gene bcl-2 and bax.Results The apoptosis of endometriosis tissues in the integrated Chinese and western medicine group was the most obvious result with the highest apoptosis index,and the positive expression of apoptosis regulating gene bcl-2 was downward regulated and that of apoptosis regulating gene bax upward regulated,so bcl-2/bax decreased.Then it was Chinese medicine group,western medicine group,and model group.Conclusion The occurrence of endometriosis is related with the lowering of ability of apoptotic cells.Chinese medicines with the functions to reinforce kidney and activate blood can promote the ability of apoptotic cells in endometriosis to quicken the atrophy and regression of endometriosis tissues.
