Hypothermia postconditioning protects hippocampal CA1 neurons from focal cerebral ischemia in tree shrew
- VernacularTitle:亚低温后适应对树鼩局部脑缺血海马CA1区神经元的保护机制
- Author:
Fei LI
;
Shuqing LI
- Publication Type:Journal Article
- Keywords:
Photochemistry;
Brain ischemia;
Vascular endothelial growth factors;
Hypothermia postconditioning
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the changes in vascular endothelial growth factor (VEGF) expression and the cell numbers of cellular necrosis in hippocampus CA1 area after cerebral ischemia and hypothermia postconditioning (HPC). METHODS: The focal thrombotic cerebral ischemia was induced by photochemical reaction in tree shrews. 6 h after ischemia, HPC was executed by a focal homoeothermic equipment, which reduced the brain temperature and maintained at 31-32 ℃ for 1 h. VEGF expression in hippocampus CA1 area was detected by immunohistochemistry. The numbers of death cells were counted and the ultrastructure was observed under the electron microscope. RESULTS: Compared to control group, VEGF expressions increased in neuron of hippocampus CA1 area at 24 h, and decreased at 72 h in HPC group (P
