Effects of local application of simvastatin on osteoporotic fracture healing in rats
- VernacularTitle:辛伐他汀局部注射对大鼠骨质疏松性骨折愈合的影响
- Author:
Jianwei WANG
;
Shaowen XU
;
Disheng YANG
- Publication Type:Journal Article
- Keywords:
Hydroxymethylglutaryl-CoA reductase inhibitors;
Simvastatin;
Osteoporosis;
Fracture healing;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:Many studies have documented an anabolic effect of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, on undisturbed bone. Reports of their effects on fractured skeleton were limited. A study was therefore conducted to check the effects of statins on fracture healing. METHODS: Simvastatin (10 mg?kg-1?d-1) was injected subcutaneously to tissue overlying the site of fractured tibiae of ovariectomized rats for a treatment period of 5 d. Vehicle reagent was used as control. Healing quality was evaluated at 1, 2 and 4 weeks after fracture. RESULTS: Compared with vehicle group, callus cross section area in simvastatin treated rats were significantly enlarged by 21.3% (P
