Ca_V 2.3 voltage-gated calcium channel and epilepsy
- VernacularTitle:Ca_V 2.3电压门控性钙通道与癫痫
- Author:
Xi YANG
;
Zhuo YANG
;
Tao ZHANG
- Publication Type:Journal Article
- Keywords:
Calcium channels,CaV 2.3 voltage-gated;
Epilepsy
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The CaV 2.3 encoded Ca2+ channel is one of the least well-known voltage-gated calcium channels in terms of physiology, pharmacology and clinical relevance. Epilepsy is a family of neurological disorders that are common and harmful to human health. More and more studies such as gene knock-out experiment have demonstrated that the channel is related to epileptic seizure, including participating to plateau potential generation, regulating intracellular Ca2+ concentration, CaV 2.3 splice variant, interacting with some muteins. In addition, some antiepileptic drugs inhibit the epileptiform discharges by targeting CaV 2.3 voltage-gated calcium channel.
