The Role of Cytokines and its Advance of Clinical Applications in Atherosclerosis
- VernacularTitle:细胞因子在动脉粥样硬化中的作用及临床应用进展
- Author:
Ziyun SHAO
;
Yi PENG
- Publication Type:Journal Article
- Keywords:
Cytokine;
Atherosclerosis;
Clinical application;
Cytokine-associated signal pathway;
Biomarker;
Treatment
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a chronic inflammatory disease of the vascular walls. As the essential mediators of inflammation, cytokines play important roles in atherosclerosis. Through widespread and penetrating studies, many cytokines, such as TNF-, IL-1, IL-6 and IFN-, are found involved in the development of atherosclerosis, as well as the related signal transduction pathways such as the NF- B pathway, the JNK / AP-1 pathway, and the JAK / STAT pathway. This implies that cytokines have a favorable perspective of clinical application. A few cytokines are identified as biomarkers, which help the early diagnosis of the disease and estimation of the risk of the clinical vascular events. Meanwhile, great progress has been made on the cytokine-targeted treatment of atherosclerosis, providing a novel therapy in the treatment of the disease.
