Optimization of Determination Method of Gentamycin Sulfate Sustained-release Tablets
- VernacularTitle:硫酸庆大霉素缓释片含量测定方法探讨
- Author:
Songwen SONG
- Publication Type:Journal Article
- Keywords:
Gentamycin sulfate;
Sustained-release tablets;
Content determination;
Sample treatment method
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To optimize the sample treatment method in the content determination of gentamycin sulfate sustained-release tablets.METHODS: In the light of the characteristics of the preparation technology of sustained-release tablets,the contents of the same sample treated by 4 methods were compared.Method 1 was a method adopted from Chinese Pharmacopeia;The solution time was increased differently in method 2 and method 3,and method 4 was similar to method 3,but in which additional grinding treatment was performed.RESULTS: Compared with marked value,the approaching degree by method 4 was the highest,followed by method 3,method 2 and method 1,respectively.The average recovery rates for method 1 and method 4 were 91.1%(RSD=1.46%) and 99.8%(RSD=0.74%),respectively.CONCLUSION: Method 4 is the optimal one for sample treatment and it is suitable for the determination of the content of this preparation.
