Mechanisms of Effects of Indol-2,3-dione on Quail Experimental Atherosclerosis
- VernacularTitle:2,3-吲哚醌抗鹌鹑动脉粥样硬化作用及其机制研究
- Author:
Zhantao LIU
;
Wang YUE
;
Zhihong YANG
;
Weizhen ZHONG
;
Yongjuan ZHAO
- Publication Type:Journal Article
- Keywords:
Indol-2,3-dione;
Quail;
Atherosclerosis;
Hyperlipemia;
Preventive effect
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the possible mechanisms of the effects of indol-2,3-dione (MW147) on experimental atherosclerosis (AS). METHODS: A total of 120 male quails were randomly divided into six groups: normal control group, model group, lovastatin (79.5 mg?kg-1) positive control group, and MW147 (20, 60, 120 mg?kg-1) groups. The normal control group was fed on normal diet, while the other 5 groups were fed on high lipid diet and treated ig with corresponding drugs for eight weeks. Then the lipid levels including TC, TG, L-DLC and H-DLC in serum and tissues, and the total superoxidedismutase (T-SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC) and malondialdehyde (MDA) were determined. Meanwhile the tissues of aorta and liver were observed under light microscope. RESULTS: In MW147-treated groups compared with model group, the levels of TC, TG, LDL-C and MDA were decreased while the levels of HDL-C, T-SOD, GSH-Px and T-AOC in serum were increased (P
